nephritis following totalbody irradiation and cyclo, phosphamide in preparation for bone marrow trans. When accompanied by associated respiratory failure, mortality rate was higher (93% vs. 33%; p less than .0001). Before the development of modern chemotherapy, virtually all children having any kind of leukemia died within a few months of diagnosis. 0000027072 00000 n 0000023587 00000 n Autoimmune complications of chronic lymphocytic leukemia. After adjustment for baseline characteristics, treatment at an NCI-CC was associated with lower early mortality (odds ratio, 0.46; 95% confidence interval, 0.38-0.57). 0000056969 00000 n Acute promyelocytic leukaemia (APML) is a rare sub-type of acute myeloid leukaemia (AML) and is sometimes referred to as AML M31. Leukemia is a clonal proliferation of hematopoietic stem cells in the bone marrow. 0000003406 00000 n We do not capture any email address. APML accounts for only 10% of all AML diagnoses. Kidney Int 1994; 46:1443-, bone marrow transplantation for hematologic malig, nancies following etoposide, cyclophosphamide, and, fractionated total body irradiation. Zhonghua nei ke za zhi [Chinese journal of internal medicine]. endstream endobj 50 0 obj <>>> endobj 51 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>>>/Rotate 0/TrimBox[0.0 0.0 612.0 792.0]/Type/Page>> endobj 52 0 obj <>stream 0000010904 00000 n %��������� Three quarters of these children have acute lymphoblastic leukemia; the remainder have acute nonlymphocytic or chronic leukemia. drome developed in a patient with acute promyelo-, cytic leukemia treated with daunomycin. Acute renal injury is associated with high mortality in cancer patients [31]. 0000012312 00000 n In this report, we describe several clinical characteristics of AKI due to primary tumor infiltration. Transplantation 1986; 41:63-6. nous nephropathy with graft-versus-host disease in a. bone marrow transplant recipient. phoblastic leukaemia in the elderly: characteristics and, outcome with the vincristine-adriamycin-dexametha-. versus-host disease. No recent stud-, ies give data on the incidence and risk factors of. 0000004838 00000 n 0000062552 00000 n During the first 100 days 12 high risk patients (43%) died from causes unrelated to relapse while none of the standard risk patients died. The pediatrician caring for these children must be aware of common infectious complications and their management. Three hundred and forty-five patients were included in the study. Acute kidney injury requiring continuous renal replacement therapy is a serious treatment-related complication in pediatric cancer and hematopoietic stem cell transplant patients. The separation time was 43 minutes. Among the patients treated with a bone marrow, transplant, 27 patients (50%) had renal complica-, tions, 4 patients before, 23 patients between day 0, and 100 after the bone marrow transplant and 4, patients later (4 patients had complications during, more than one period). Acute, renal failure has an especially poor prognosis. Urine production did not reach the critical limit of oliguria. Renal failure occurring as a consequence of terminal multi-organ failure was excluded from the present study. ;�s}M��FOAf�30�n���$ ` �L� endstream endobj 741 0 obj <>/Filter/FlateDecode/Index[64 606]/Length 43/Size 670/Type/XRef/W[1 1 1]>>stream They are chemotherapy, exposure to radiation, some chemicals, Down syndrome and smoking. Acute renal failure in patients, Harris KPG, Hattersley JM, Feehally J, et al. Renal parameters should be monitored fre, quently to avoid acute renal failure which is prognos-, tically unfavorable in all patient categories. 0000009916 00000 n Hematol Oncol 1994; failure at onset of therapy for advanced stage Burkitt. 0000005411 00000 n �} �� . David G. Poplack 1. Cyclosporine as. 0000024982 00000 n a more recent study in untreated ALL, an incidence of, 13 respectively 25% was noted depending on the age, monoblastic leukemia, renal impairment was found. Prognostic analysis using both univariate and multivariate (stepwise regression) methods. The median age was 25.5(9-48) years. Eight PICUs of a tertiary care hospitals in the Netherlands. The association between monosomy 7 and DI in AML appears specific but the reason for this association remains unclear. The duration of a renal complication was scored, until the pathological parameters had normalized for, at least one week. Blood 1989; 73:2018-, phosphatemie et insuffisance renale transitoire aprés, chimiotherapie d’une leucemie Iymphoblastique, acute Iymphoblastic leukemia. Patients with acute acute promyelocytic, leukemia were on low-dose heparin during the induc, tion treatment. Beyond day, 100 after transplantation, renal complications were, less frequent and had no clear impact on prognosis, In some but not all earlier studies, renal failure was, described as an unfavorable prognostic criterion in, lyzed the incidence of renal failure in unselected, patients. You may be able to gain access using your login credentials for your institution. no influence on the risk of early or late complications, especially monoblastic leukemias, which were not, associated with an increased risk for kidney dysfunc-, In the transplant group, only the type of transplant, (allogeneic versus autologous) had an influence on, the risk of renal dysfunction (see Table 2, 4 patients, with complications before transplantation are not. Non-ATN causes (urate nephropathy or obstruction) carried a better prognosis. Data of 73 acute leukemia patients performed ABMT in our hospital from October 1986 to December 1997 were retrospectively analyzed.
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