Clonal: Neoplastic proliferation of eosinophils in a stem cell-derived myeloid malignancy. 2019 Oct 21;191(42):E1159-E1163.
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However, one should be aware that moderate and severe hypereosinophilia from conditions such as hypereosinophilic syndrome can result in multiorgan damage and complications including cardiomyopathy, pneumonitis, neuropathy, gastrointestinal inflammation, or thromboembolic complications. Drug reaction with eosinophilia and systemic symptoms (DRESS), also termed drug-induced hypersensitivity syndrome (DIHS), is a rare reaction to certain medications.It involves primarily a widespread skin rash, fever, swollen lymph nodes, and characteristic blood abnormalities such as an abnormally high level of eosinophils, low number of platelets, and increased number of atypical white … Name must be less than 100 characters PMID: 29669671 [Indexed for MEDLINE] Publication Types: Case Reports; Review View All Procedures >
A thorough history and physical exam should help guide the determination of what diagnostic tests will be most high-yield. Hypereosinophilic syndrome (HES), characterized by persistent eosinophilia >1500 cells/microL (typically on two separate occasions), no other identifiable etiology, and signs or symptoms of organ involvement. Ear/Nose/Throat: nasal and sinus inflammation can point towards allergic rhinitis, eosinophilic granulomatosis with polyangitis (previously Churg-Strauss), or granulomatosis with polyangiitis (previously Wegener’s disease). Toxins: eosinophilia-myalgia syndrome from ingestion of contaminated L-tryptophan, toxic oil syndrome from ingestion of adulterated oil with denatured rapeseed oil. All rights reserved.
doi: 10.1016/j.jaci.2014.09.034.
Consider serum Tryptase level to evaluate for systemic mastocytosis. Immunodeficiency states: hyper-immunoglobulin E (IgE) syndrome which is characterized by chronic dermatitis and recurrent infections. Close more info about Eosinophilia Although most cases of drug-induced eosinophilia are asymptomatic, one study showed an increased rate of hypersensitivity reactions in patients with higher eosinophil counts and earlier onset of eosinophilia.
2015 Mar;135(3):822-4.e2. Hypereosinophilic syndrome (HES) is a myeloproliferative disorder (MPD) characterized by persistent eosinophilia that is associated with damage to multiple organs. Drugs in Eosinophilia. Imatinib treatment may result in myelosuppression, gastrointestinal side effects, rash, and peripheral/periorbital edema. This syndrome tends to have an unknown cause or results from certain types of cancer, such as bone marrow or lymph node cancer. The Manual was first published as the Merck Manual in 1899 as a service to the community. Toxins suspected to cause eosinophilic pneumonia include cigarette smoke and illicit drugs. Chronic eosinophilic leukemia not otherwise specified. Testing can include some of the tests previously mentioned as well as lactate dehydrogenase (LDH) and liver tests (suggesting liver damage or possibly a Drugs known to be associated with eosinophilia are stopped. Such a trial is indicated if eosinophilia is persistent and progressive in the absence of a treatable cause.Merck & Co., Inc., Kenilworth, NJ, USA (known as MSD outside of the US and Canada) is a global healthcare leader working to help the world be well.
Eosinophils are a type of disease-fighting white blood cell. Eosinophilia can result from a variety of conditions, diseases, and factors, including:
suspected to cause eosinophilic pneumonia include cigarette smoke and illicit drugs. Drug- or toxin-induced eosinophilic pneumonia is indistinguishable from idiopathic acute or chronic eosinophilic pneumonia by clinical, radiographic, and histopathologic criteria. FISH/ RT-PCR results can identify particular clonal eosinophilias with FIP1L1-PDGFR genetic rearrangements. Antibiotics and NSAID, are the most commonly reported drugs. Common causes (eg, allergic, infectious, or neoplastic disorders) should be considered first, but even they are often difficult to identify, so a thorough history and physical examination are always required.The questions most likely to be helpful pertain to the following:Use of herbal products and dietary supplements, including L-tryptophanSystemic symptoms (eg, fever, weight loss, myalgias, arthralgias, rashes, lymphadenopathy)Systemic symptoms suggest that a minor allergic or drug cause is less likely, and a detailed evaluation for an infectious, neoplastic, connective tissue, or other systemic disorder should be done.
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If work-up unrevealing and/or clinical picture points to a primary etiology of eosinophilia: Important Disorders and Treatments Associated With Eosinophilia
Use patient history to target possible etiologies above and assess for possible culprit medications. doi: 10.1503/cmaj.190669.Allergy Asthma Proc. J Allergy Clin Immunol. Infectious and autoimmune processes can be distinguished with positive testing and the clinical picture. Epub 2014 Oct 30.Kaldenbach T, Schäfer D, Gosepath J, Bittinger F, Klimek L, Mann WJ.Laryngorhinootologie.
Antibiotics (penicillins, cephalosporins, quinolones, sulfonamides). 2005 Dec;37(10):380-6.CMAJ. This is the Professional Version. Unable to load your collection due to an error Tables (1)
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